Isaac Guerendo

24-Year-Old Running BackRB

San Francisco 49ers

Questionable

Injury Knee - MCL

Est. Return 2/10/2025

2024 Rush/Rec Stats

ATT

YDS

420

YDS

152

Rest-of-Season Projections

ATT

YDS

Unlock Our Projections

2024 Fantasy Outlook

A 4.33 40-yard time and a strong overall performance at the Combine launched Guerendo up draft boards, and the 49ers traded up in the fourth round to make sure they got the 221-pound speedster. Kyle Shanahan's offense is arguably the best in the league for a running back, especially one with game-breaking speed, though Guerendo figures to begin his career behind three-down workhorse Christian McCaffrey and the brittle Elijah Mitchell. Guerendo was never a lead back during his time at Wisconsin and Louisville, but he averaged 6.1 yards on 132 carries for the Cardinals last season and now becomes one of the fastest running backs in the NFL. Read Past Outlooks

RANKS

#450.21

ADP

Overall

Running Back

Bye Week 9

Height 6'0"

Weight 221

DOB 6/28/2000

College Louisville

Drafted 4th Rd 2024 #129 Overall

Has MCL, ankle sprains

RBSan Francisco 49ers

Knee - MCL

January 6, 2025

Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, Matt Barrows of The Athletic reports.

ANALYSIS
The 49ers' 2024 campaign is over, but the team's season finale included yet another RB injury. On only his second carry of Sunday's game, Guerendo had his left leg twisted under him as he was tackled, and he needed a cart to go to the locker room. While Guerendo did avoid a more serious ACL injury, he's still one of four San Francisco running backs who will enter the offseason focusing on rehab, along with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective when given the chance as a rookie, turning 84 carries into 420 yards (5.0 YPC) and four touchdowns and hauling in 15 of 16 targets for 152 yards in 16 appearances.

Read More News

NFL Stats

Loading NFL Stats...

Fantasy/Red Zone Stats

See red zone opportunities inside the 20, 10 and 5-yard lines along with the percentage of time they converted the opportunity into a touchdown.

Loading Fantasy/Red Zone Stats...

Advanced NFL Stats

How do Isaac Guerendo's 2024 advanced stats compare to other running backs?

This section compares his advanced stats with players at the same position. The bar represents the player's percentile rank. For example, if the bar is halfway across, then the player falls into the 50th percentile for that metric and it would be considered average. The longer the bar, the better it is for the player.

Broken Tackle %
The number of broken tackles divided by rush attempts.
Positive Run %
The percentage of run plays where he was able to gain positive yardage.
% Yds After Contact
The percentage of his rushing yards that came after contact.
Avg Yds After Contact
The average rushing yards he gains after contact.
Rushing TD %
Rushing touchdowns divided by rushing attempts. In other words, how often is he scoring when running the ball.
Touches Per Game
The number of touches (rushing attempts + receptions) he is averaging per game
% Snaps w/Touch
The number of touches (rushing attempts + receptions) divided by offensive snaps played.
Air Yards Per Game
The number of air yards he is averaging per game. Air yards measure how far the ball was thrown downfield for both complete and incomplete passes. Air yards are recorded as a negative value when the pass is targeted behind the line of scrimmage. All air yards data is from Sports Info Solutions and does not include throwaways as targeted passes.
Air Yards Per Snap
The number of air yards he is averaging per offensive snap.
% Team Air Yards
The percentage of the team's total air yards he accounts for.
% Team Targets
The percentage of the team's total targets he accounts for.
Avg Depth of Target
Also known as aDOT, this stat measures the average distance down field he is being targeted at.
Catch Rate
The number of catches made divided by the number of times he was targeted by the quarterback.
Drop Rate
The number of passes he dropped divided by the number of times he was targeted by the quarterback.
Avg Yds After Catch
The number of yards he gains after the catch on his receptions.
% Targeted On Route
Targets divided by total routes run. Also known as TPRR.
Avg Yds Per Route Run
Receiving yards divided by total routes run. Also known as YPRR.

Broken Tackle %

10.7%

Positive Run %

81.0%

% Yds After Contact

79.3%

Avg Yds After Contact

4.0

Rushing TD %

4.8%

Touches Per Game

6.2

% Snaps w/Touch

45.0%

Air Yards Per Game

3.1

Air Yards Per Snap

0.23

% Team Air Yards

1.2%

% Team Targets

3.1%

Avg Depth of Target

3.1 Yds

Catch Rate

93.8%

Drop Rate

0.0%

Avg Yds After Catch

7.1

% Targeted On Route

16.2%

Avg Yds Per Route Run

1.54

Loading Advanced NFL Stats...

2024

2024 NFL Game Log

Calculate Stats Over Time

Just click on any two dates.

Scoring

Standard

PPR

Half PPR

FanDuel

DraftKings

Yahoo DFS

Loading Game Log...

Snap Distribution / Depth Chart

Snap Counts

Snap %

49ers 2024 RB Snap Distribution See more data like this | See last season's snap counts

J.Jordan Mason

I.Isaac Guerendo

P.Patrick Taylor

C.Christian McCaffrey

K.Ke'Shawn Vaughn

#% of Team Snaps

35935%

22021%

16316%

15715%

30%

Loading Weekly Snap Counts...

#1 RB

49ers

View Full Depth Chart

Receiving Alignment Breakdown

See where Isaac Guerendo lined up on the field and how he performed at each spot.

Detailed

Grouped

Side

Loading Alignment Breakdown...

Loading Team Alignment Breakdown...

2024 Isaac Guerendo Split Stats

Loading NFL Split Stats...

Measurables Review View College Player Page

How do Isaac Guerendo's measurables compare to other running backs?

This section compares his draft workout metrics with players at the same position. The bar represents the player's percentile rank. For example, if the bar is halfway across, then the player falls into the 50th percentile for that metric and it would be considered average.

Height

6' 0"

Weight

221 lbs

40-Yard Dash

4.33 sec

Shuttle Time

4.15 sec

Cone Drill

6.94 sec

Vertical Jump

41.5 in

Broad Jump

129 in

Hand Length

9.25 in

Arm Length

30.75 in

Recent RotoWire Articles Featuring Isaac Guerendo See More

Box Score Breakdown: Week 18 Usage & 2025 ADP Estimates

8 days ago

Ravens TE Mark Andrews finished the season strong and should stay busy during the playoffs, especially if WR Zay Flowers is sidelined by a knee injury

NFL Reactions: Week 18 Recap

10 days ago

Jim Coventry reacts to Week 18, including Mike Evans, who recorded his 11th consecutive season with 1,000 receiving yards.

NFL DFS Picks: Yahoo Plays and Strategy for Week 18

12 days ago

The top NFL DFS options for Week 18's main slate on Yahoo include rookie running back Bucky Irving as the Tampa Bay Buccaneers try to secure the NFC South title against the New Orleans Saints.

NFL Game Previews: Week 18 Matchups

13 days ago

The Week 18 comes down to a Sunday night showdown between the Lions and Vikings with the NFC's No. 1 seed on the line. Erik Siegrist previews the games.

Exploiting the Matchups: Week 18 Start/Sit and Fantasy Streamers

13 days ago

RW's Jerry Donabedian expects DJ Moore to finish the year strong against a banged-up Green Bay defense. Plus, we have the full scoop on Week 18 incentives and milestones, in addition to matchup analysis.

More Fantasy News

MCL sprain likely, tests upcoming

RBSan Francisco 49ers

Knee

January 5, 2025

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' official site reports.