This article is part of our NFL Picks series.
NFL Odds: NFL Key Line Moves for Week 16
The goal of this article is to look at the key line moves for the week and what they mean in terms of betting. Key numbers in the NFL to watch for are 3, 7, 6, 14 and 10. When a line crosses through one of these, it is a significant move that warrants attention.
Use the ESPN BET promo code ROTO, and it gives new users access to a generous bet anything to get $250 in bonus bets welcome offer, along with one of the best sports betting sites in the online sports betting world today.
NFL Week 16 Odds
Week 16 Schedule
New Orleans Saints at Los Angeles Rams -4.0 O/U 44.5 OPENED RAMS -1.0, 43.5
Cincinnati Bengals -2.0 at Pittsburgh Steelers O/U 39.0 OPENED BENGALS -2.5, 39.5
Buffalo Bills -14.0 at Los Angeles Chargers O/U 42.5 OPENED BILLS -1.0, 40.5
Indianapolis Colts -2.0 at Atlanta Falcons O/U 44.5 OPENED FALCONS -2.5, 42.5
Green Bay Packers -4.0 at Carolina Panthers O/U 36.0 OPENED PACKERS -1.0, 36.0
Cleveland Browns at Houston Texans -2.5 O/U 42.0 OPENED BROWNS -4.0, 41.0
Detroit Lions -3.5 at Minnesota Vikings O/U 47.0 OPENED VIKINGS -1.0, 46.0
Washington Commanders at New York Jets -3.0 O/U 38.0 OPENED JETS -5.5, 40.0
Seattle Seahawks -2.5 at Tennessee Titans O/U 42.5 OPENED SEAHAWKS -2.0, 44.0
Jacksonville Jaguars at Tampa Bay Buccaneers PICK O/U 45.0 OPENED JAGUARS -3.5, 44.5
Arizona Cardinals at Chicago Bears -4.0 O/U 44.5 OPENED BEARS -4.0, 43.5
Dallas Cowboys at Miami Dolphins -1.5 O/U 51.0 OPENED DOLPHINS -1.5, 48.5
New England Patriots at Denver Broncos -5.5 O/U 36.5 OPENED BRONCOS -1.5, 41.0
Las Vegas Raiders at Kansas City Chiefs -10.0 O/U 43.0 OPENED CHIEFS -8.5, 42.0
New York Giants at Philadelphia Eagles -10.0 O/U 43.5 OPENED EAGLES -7.5, 44.0
Baltimore Ravens at San Francisco 49ers -5.0 O/U 45.5 OPENED 49ERS -3.0, 45.0
Kick off the NFL season at Caesars Sportsbook using our Caesars Sportsbook promo code for your $250 in bonus bets. Be sure to check out the odds differences across the best sports betting sites, as well as the best sportsbook promos to get the most bang for your buck this season.
Week 16 Key Injury News
Jaguars - QB Trevor Lawrence (concussion)
Ravens - RB Keaton Mitchell (knee)
Bills - DT Jordan Phillips (wrist)
Cowboys - OG Zack Martin (quad)
Titans - QB Will Levis (leg)
Jets - QB Zach Wilson (concussion)
Packers - WR Jayden Reed (toe)
Patriots - TE Hunter Henry (knee)
Bengals - WR Ja'Marr Chase (shoulder)
Browns - OG Joel Bitonio (back)
Dolphins - WR Jaylen Waddle (chest)
Colts - WR Michael Pittman (concussion)
Week 16 observations
Highest point spread – Bills/Chargers -14.0
Lowest point spread – Jaguars/Bucs PICK
Highest total – Cowboys/Dolphins 51.0
Lowest total – Packers/Panthers, Patriots/Broncos 36.0
Two games with totals over 46.5 - Cowboys/Dolphins, Lions/Vikings
Four games with totals of 39 or less – Bengals/Steelers, Packers/Panthers, Commanders/Jets, Patriots/Broncos
Three games with lines at least -10.0 or higher – Bills/Chargers, Raiders/Chiefs, Giants/Eagles
The BetMGM bonus code gets new customers access to a first-bet offer worth up to $1,500.
NFL Week 16 Line Movement: Buffalo Bills 
at Los Angeles Chargers 
This might be the biggest line move of the season from opening to now, with the Bills opening at -1.0 and now all the way up to -14.0. The Chargers fired their head coach and general manager, and Justin Herbert is out for the season, so they have nothing to play for. Oh, by the way, the Raiders destroyed them last week, 63-21, and were down 42-0 at halftime.
The Bills are making another run at the playoffs and need to win out in order to make it. They are coming off a huge win against the Cowboys, 31-10.
New users can take advantage of the FanDuel promo code that opens up $200 in bonus bets.
NFL Week 16 Line Movement: Indianapolis Colts 
at Atlanta Falcons 
It is hard to imagine the Colts are now a -2.0 road favorite against the Falcons as the Colts are playing with Gardner Minshew and the Falcons were the favorites in the NFC South just a few weeks ago. The Falcons opened -2.5 home favorites originally.
But the Falcons are 2-5 in their last seven, including an awful loss to the Panthers, 9-7, which pretty much ended their playoff hopes. Meanwhile, the Colts are in a good spot to make the playoffs and have a lot of motivation.
Sign up at the DraftKings Sportsbook using RotoWire's DraftKings Promo Code for a $200 welcome offer.
NFL Week 16 Line Movement: Cleveland Browns 
at Houston Texans 
The Browns opened -4.0 road favorites and now the Texans are -2.5 home favorites for a 6.5-point line move. This looks to be the right value with C.J. Stroud expected to play and the Browns defense is not the same unit on the road. This is a huge game for both teams' playoff hopes.
NFL Week 16 Line Movement: Detroit Lions 
at Minnesota Vikings 
The Vikings originally opened as -1.0 home favorites, but the injury to Kirk Cousins along with their quarterback carousel has the Lions now as -4.5 road favorites. The Lions got a much-needed win against the Broncos on Saturday, while the Vikings lost in overtime to the Bengals. This is a must-win game for the Vikings and the Lions are not as strong on the road. This feels like a bit too much of a line move in favor of the road team in this divisional matchup.
NFL Week 16 Line Movement: New England Patriots 
at Denver Broncos 
Most of the games with significant line moves now will be due to a major injury or a team being out of playoff contention. The Patriots have nothing to play for while the Broncos are fighting for a playoff spot. The Broncos originally opened as -1.5 home favorites, but it has moved to -5.5. The total has moved also from an opening number of 41.0 all the way down to 36.5, which still feels too high.
If you're betting on the NFL this season, RotoWire has a full suite of betting pages and tools with everything you need from the latest NFL odds to weekly NFL picks along with a wide variety of NFL futures and NFL player futures.
