If the Jets really mean to commit to the ground game then they'll have to prove it by feeding Breece Hall against the Bills on Monday.
Tyrone Tracy showed up big for the Giants in Week 5, and they'll need to call on him again with Devin Singletary (groin) unavailable against Cincinnati on Sunday night.
Derek Carr has a career average of just 6.3 yards per pass against the Chiefs, and now he needs to play at Arrowhead with an interior offensive line decimated by injury.
Dak Prescott is without Brandin Cooks against a dangerous Pittsburgh defense, but he should need to throw the ball often given Dallas' rushing struggles.
Despite three weeks of struggles to open the 2024 season, Jared Goff is in a good bounce-back spot Monday night.
The Miami run defense is much more inviting than any Tony Pollard has seen in his first three games with Tennessee.
Derrick Henry finally got rolling in Week 3, but he faces a much tougher defense Sunday night than the Dallas one from Week 3.
The Commanders are heavy road underdogs, but Brian Robinson should still be busy against a beat-up and questionable Bengals run defense.
Josh Allen could do big damage Monday, but it's also not clear if the Bills will need to ask much of him against a sinking Jaguars squad.
With both offenses struggling through two weeks it's likely crucial to pursue Bijan Robinson's assured usage in single-game lineups between Atlanta and Kansas City on Sunday night.
With A.J. Brown (hamstring) unavailable, DeVonta Smith becomes extremely difficult to fade against Atlanta on Monday.
C.J. Stroud is generally stronger at home than on the road, but the Bears defense is strong enough to raise the difficulty level Sunday night.
There's both hope and apprehension for the Jets offense as Aaron Rodgers returns from last year's Achilles' tendon tear on the road and against a dangerous 49ers defense.
Jahmyr Gibbs is reportedly over his hamstring injury, setting up for a monster box score against the Aaron Donald-less Rams on Sunday night.
There's a lot to keep track of as the Eagles face the Packers, but the headlining stories might be star free agent RB pickups Saquon Barkley and Josh Jacobs.
Fair or not, all the pressure is on Jalen Hurts as the Eagles try to stop their slide in Tampa Bay.
Josh Allen and the Bills offense have struggled lately, but the Miami defense has been a reliable punching bag for Allen.
Jaren Hall should find it easy to get the ball to Justin Jefferson against Green Bay's weakened corner rotation.
Ezekiel Elliott might be a heavy road underdog, but he should still see plenty of work against Denver.
Dallas Goedert could get going Monday night, especially if rainy conditions make it difficult to throw downfield.
Gus Edwards' usage could turn for the better if weather forces the Ravens to run more than usual Sunday night.
AJ Dillon needs to show more, but the friendly Giants run defense could help him do just that Monday.
Tyreek Hill is on a blistering pace in 2023 and the Titans pose no obvious way to slow him down.
For Dak Prescott to stay in the MVP conversation he'll need to stay hot against Philadelphia on Sunday.
Trevor Lawrence will try to make it three strong games in a row as the home-team Jags face Cincinnati.
The Vikings' blitzing tendencies versus Justin Fields' big-play ability could make for a boom-or-bust proposition Monday.
Keenan Allen gets a tough matchup against the Ravens on Sunday, but the Chargers have nowhere else to throw the ball.
Tyreek Hill struggled against the Jets in 2022, but the Dolphins were without Tua Tagovailoa for both of those games.
DeVonta Smith has been in A.J. Brown's shadow all year, but with Dallas Goedert out Philadelphia needs both WRs to produce Monday.
T.J. Hockenson has been unstoppable for Minnesota since Justin Jefferson's injury, setting up another big game against Denver.