Obviously, the big news is Ryan Mathews out 4-6 weeks with a broken clavicle. Even if he were back for Week 1 or 2, it's hard not to see him as a Darren McFadden-level injury risk at this point - and remember - McFadden's healthy right now. Look for Ronnie Brown to see extra work early on - unless the Chargers bringing in the carcass of Cedric Benson or Ryan Grant.
Jeremy Maclin missed Thursday's game with a hamstring injury. This could be nothing - or it could be the start of a nagging problem a la Miles Austin or Andre Johnson last year.
Peyton Manning passed the eye test in his preseason debut. It's not dispositive of his health or level of play, but it's a good start, especially in the first preseason game.
Michael Vick left Thursday's game after banging his throwing hand on a pass-rusher's helmet, but x-rays were negative, and apparently the injury wasn't too serious.
Sidney Rice hopes to participate in contact drills next week. "Hopes" doesn't mean a whole lot, but it sounds like it's at least possible he'll get up to speed at the end of the month. The Seahawks brought in some of the best talent from 2007 in case that doesn't happen.
Trent Richardson underwent successful knee surgery Thursday and is expected to play Week 1. How many carries he'll get and what kind of football shape he'll be in remain to be seen.
There are glowing reports about Christian Ponder in Vikings camp from unlikely sources such as WR Percy Harvin. This could be noise, but quarterbacks typically improve a good deal from Year 1 to Year 2, and keep in mind Ponder's rookie year had no offseason, and he was the backup to Donovan McNabb throughout last year's training camp.