I wouldn't concern myself too much with Frank Gore breaking his hand. In fact, one might even construe it as good news, as he's now less likely to suffer a serious injury during training camp. He'll be able to stay in shape and should enter the season with fresh legs. He's a playbook junkie, so he'll know the new system, and the less preseason work, the better when it comes to running backs. LaDainian Tomlinson didn't have one carry in the fake games last year.
Brandon Jackson has gotten off to a slow start in early camp work, but Vernand Morency's recent knee injury that will sideline him for two weeks highlights his biggest weakness – durability. This is a guy who has never carried the ball 100 times in a season, and Jackson is familiar with the zone-blocking scheme (he played under the same system in college), so his pass-protection problems will improve in time. He's clearly the one to be targeting in fantasy leagues, and with Green Bay's defense on the upswing, there's a decent amount of potential if given the opportunity.
It's easy to forget, but Daunte Culpepper has averaged 7.7 YPA during his career. Sure, Randy Moss had a big part in that, but 7.7 is seriously good. That said, there are rumblings that it will take one more full year before his knee is truly recovered, leaving his availability for Week 1 in question. Judging by the fact he turned down the Jaguars' three-year proposal to sign a one-year deal with Oakland, maybe he's more confident in his knee than I am.
Everyone knows to never draft a kicker before the final round (and yet it still happens all the time, even in so-called "experts" leagues), but it's not because having the best kicker isn't a decent advantage – in fact, it is. It's just that the position is the most unpredictable of all. Adam Vinatieri won't get you many long field goals, but in that offense and with that accuracy, I'm OK with someone bidding $2 on him.
Maybe more than any other position, when to draft fantasy defenses largely depends on scoring format. Last year my selection of the Bears in round six went from looking like a reach to looking like a steal by season's end. But then again, we use yardage allowed as an additional scoring method, something the majority of leagues do not. Still, the Bears (and Ravens) were likely a lot more valuable last year than where they were drafted in almost every league. However, no team has ever been this dominant for three straight seasons, so history suggests a drop off is likely. But with Tarvaris Jackson, Brett Favre and Jon Kitna in the division, turnovers should come aplenty. I'm on board with aggressively bidding or drafting Chicago, Baltimore and maybe even San Diego, but if not, then make sure you roster at least a couple of defenses with later round picks. Like quarterbacks, defenses are the other best position to utilize matchups week-to-week.
If you don't get Antonio Gates this year, then you shouldn't be looking to address the tight end position until at least rounds 7-8.
Wherever Willie Parker is selected in your draft, it'll be considered a steal by the end of the season. Expect him to be much more active in the passing game with Bruce Arians opening things up, while continuing to get the majority of goal line looks. He's approaching top-5 territory.